Researchers examine 21-year series of nipple sparing mastectomy cases and find no cancers

ScienceDaily (Oct. 27, 2011) ? A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective, say researchers at Georgetown. They say the procedure known as a nipple sparing mastectomy is also a viable surgical option for women who choose to have their breasts removed because of their increased risk of developing the disease. For both groups of women, the surgery offers a chance for a more natural looking and normal feeling reconstructed breast as compared to other forms of mastectomy.

Nipple sparing mastectomy (NSM) involves the removal of the breast tissue while keeping intact the breast skin and nipple areola complex, which includes the nipple and darker pigmented circle of skin that surrounds it. The breast is usually reconstructed immediately.

A long standing concern with this type of surgery is that cancer cells might be left under the nipple, posing a threat over time. To examine the effectiveness of NSM, surgeons conducted a review of patient records for all women receiving the surgery at Georgetown University Hospital (GUH) between 1989 and 2010 including surgeries to either prevent or treat breast cancer. The results are published in the November issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

"Our findings were reassuring. Of the 162 surgeries performed, we found no cancer recurrences and no new cancers in those receiving NSM," says Scott Spear, M.D., professor of plastic surgery at Georgetown University Medical Center and chairman of the department of plastic surgery at GUH. "The nipple-sparing technique is not appropriate for every patient depending upon their anatomy and type of breast pathology. Careful selection of the right patient for NSM is an important element of success."

Some patients who received NSM at Georgetown had early-stage cancer or DCIS, which can become an invasive cancer if not treated properly. In fact, while the majority of women with early cancers typically have a lumpectomy, many women choose to have a mastectomy.

Georgetown breast cancer surgeon Shawna C. Willey, M.D., says the first priority always is to treat or prevent the cancer. "We need to be able to offer women options that they know will successfully treat or prevent their cancer while at the same time, preserve their quality of life whether it be in their appearance or psychologically. Nipple sparing mastectomy goes a long way toward reaching that goal." Willey is chief of breast cancer surgery at GUH, and she and Spear are members of the Georgetown Lombardi Comprehensive Cancer Center.

One step credited for why cancers didn't develop later is that biopsies were done on the tissue that remained under the nipple area after the NSM. If abnormal cells in this tissue were identified, as it was in four cases reviewed, either the nipple or entire nipple areola complex later were removed.

A second concern for this kind of surgery is that the nipple areola complex (NAC) might not receive enough blood after the tissue and blood vessels below it are removed causing necrosis or tissue death. Researchers say the records showed three NACs became necrotic and required removal. Four other NACs had partial necrosis requiring surgery though the nipple and majority of the areola was spared.

"What we've learned from this review is that our established procedures and patient-selection protocol lead to favorable results," confirms Spear. "As more data become available, I think we'll see nipple sparing mastectomy play a larger role, particularly in the prevention setting."

This work was not supported by any external funding. In addition to Spear and Willey, authors include Elizabeth D. Feldman, M.D., Costanza Cocilovo, M.D., Mary Sidawy, M.D., Ali Al-Attar, M.D., Ph.D., Catherine Hannan, M.D., Laura Seiboth, M.D., and Maurice Y. Nahabedian, M.D. Spear and Nahabedian are paid consultants to Lifecell and Allergan Corporations. None of the remaining authors report having personal financial interests related to the study.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/td4D5NnD5hg/111027083037.htm

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Spider-Man musical bids adieu to 2 original stars

FILE - In this May 12, 2011 file photo, the cast of Spider-Man: Turn Off The Dark," from left, Patrick Page, T.V. Carpio, Reeve Carney, and Jennifer Damiano pose for photographers outside the Foxwoods Theatre in New York after the first preview performance. Carpio and Damiano will end their run in ?Spider-Man: Turn Off the Dark? next month when their contracts expire. Damiano, who has played Mary Jane since performances began last November, will be replaced by Rebecca Faulkenberry. Carpio, who has been playing the Spider-woman Arachne, will be replaced by Christina Sajous. (AP Photo/Tina Fineberg, file)

FILE - In this May 12, 2011 file photo, the cast of Spider-Man: Turn Off The Dark," from left, Patrick Page, T.V. Carpio, Reeve Carney, and Jennifer Damiano pose for photographers outside the Foxwoods Theatre in New York after the first preview performance. Carpio and Damiano will end their run in ?Spider-Man: Turn Off the Dark? next month when their contracts expire. Damiano, who has played Mary Jane since performances began last November, will be replaced by Rebecca Faulkenberry. Carpio, who has been playing the Spider-woman Arachne, will be replaced by Christina Sajous. (AP Photo/Tina Fineberg, file)

(AP) ? Broadway's "Spider-Man" musical is about to lose two of its original cast members.

Producers said Friday that original stars Jennifer Damiano and T.V. Carpio will end their run in "Spider-Man: Turn Off the Dark" next month when their contracts expire.

Damiano, who has played Mary Jane Watson since performances began last November, will be replaced by Rebecca Faulkenberry, who made her Broadway debut in "Rock of Ages." Carpio, who has been playing the spider-woman named Arachne, will be replaced by Christina Sajous, who starred in "Baby, It's You!" and "American Idiot."

Reeve Carney, who plays Peter Parker and the webslinger, and Patrick Page, who is the Green Goblin, are sticking with the $75 million show, which after a difficult birth, has become a top Broadway earner.

The musical, Broadway's most expensive, was plagued by accidents and delayed premieres before finally officially opening in June.

By that time, the original director and co-book writer Julie Taymor had been ousted, and the musical's songs by U2's Bono and The Edge and the story line were reworked.

Carpio originally landed a part in the so-called Geek Chorus ? four comic book fans who framed the plot and represented Taymor, Bono, The Edge and co-book writer Glen Berger. But Carpio had been the understudy for several roles since joining the show in 2007 and was a natural choice when the original Arachne ? Natalie Mendoza ? pulled out after suffering a concussion in December.

During the show's rocky spring, the role of Arachne was reworked and Carpio suffered whiplash when one of the performers playing Spider-Man toppled onto her in March.

Damiano's last performance will be Nov. 6. Carpio's will be Nov. 13.

___

Online:

http://www.SpiderManOnBroadway.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-28-Theater-Spider-Man/id-8a8c4fe79c6b4f09852694d315cce7a6

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Keen On ? Failure Is The Ultimate Rebirth (TCTV)

Ooyala Backlot Web-7In Silicon Valley, failure has been democratized. You don?t need a lot of money to fail. Nor do you need any previous experience. Take, for example,?Brian Wong?and?Roger Dickey?? two young Silicon Valley entrepreneurs who, in spite of their youth, are already steeped in failure. Wong, who was the youngest person ever to receive venture capital funding and is now the CEO of the mobile rewards network?Kiip, once worked at Digg ? the paragon of a failed Silicon Valley technology start-up. While Dickey managed to build 16 sixteen (yes, that?s SIXTEEN) failed Facebook apps before getting lucky with Mafia Wars. When I spoke to Wong and Dickey earlier this week at?FailCon,?they both embraced the idea of failure. It?s all about ?mental resilience?, they told me. Every setback is a ?learning opportunity?, they said, and they described failure as ?the ultimate rebirth?. Great failures of the past include Thomas Edison and the Wright Brothers, they explained, while Groupon?s Andrew Mason and Zynga?s Mark Pincus are today?s heroic failures, guys who failed so fast and frequently that in the end that had to get something right.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/K9twJZ4m8os/

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AnandTech - Dell Introduces Latitude ST Business Tablet

Dell today announced its Latitude ST, a 10.1" 1.8 pound Windows 7 tablet aimed directly at Windows-centric IT shops.

There's nothing particularly inspiring about the Latitude ST's hardware: a 1.5 GHz single-core Atom Z670 and an Intel GMA 600 integrated graphics chip (which, like the GMA 500, is actually a licensed PowerVR SGX core) drive its 1280x800 screen, which is made of Gorilla Glass and accepts both stylus and multitouch input. 2GB of RAM comes standard, and storage (presumably in the form of an SSD) of up to 128GB will be available.

Wireless n (1x1 only, unfortunately) and Bluetooth 4.0 are standard, and an optional Dell Wireless 5550 HSPA+ card can provide cellular data and GPS functionality. Integrated rear (5 megapixel) and front ("720p HD") cameras, an SD card slot, and an HDMI port round out its multimedia capabilities.

Despite these rather weak specs, there are a few bullet points which might sway Windows-centric IT managers, including its wired gigabit LAN port, three USB 2.0 ports, and TPM chip (used primarily with disk encryption software like Bitlocker). An optional docking station can add a physical keyboard to the device. However, pricing information, one factor to which businesses are always sensitive, has not been revealed.

With these business-centric features, Windows compatibility, and the Latitude name, the ST may find a small niche in some IT shops, but with Windows 8 buzz building and increasing support for iOS and Android devices in the enterprise, it seems like a bit of a long shot.

Source: Dell

Source: http://www.anandtech.com/show/5023/dell-introduces-latitude-st-business-tablet

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Raider in Canada, Pwned by the RAZR! [From the Forums]

From the Forums

With all the talk of exclusivity and such, let me just say.. this post is exclusive to Android Central. With that out the way -- plenty of Android news happned already today so make sure you get caught up either here on the blogs or in the exclusive Android Central forums. Also, stay tuned for the Greatest Android Podcast in the world.

If you're not already a member of the Android Central forums, you can register your account today.


Source: http://feedproxy.google.com/~r/androidcentral/~3/7dGgj06OY5E/raider-canada-pwned-razr-forums

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Claims for unemployment aid dip but remain high

Job seekers talk with prospective employers at a job fair Wednesday, Oct. 26, 2011, in Brookpark, Ohio. The number of people seeking unemployment benefits dipped slightly last week, though not by enough to suggest that hiring is picking up.(AP Photo/Tony Dejak)

Job seekers talk with prospective employers at a job fair Wednesday, Oct. 26, 2011, in Brookpark, Ohio. The number of people seeking unemployment benefits dipped slightly last week, though not by enough to suggest that hiring is picking up.(AP Photo/Tony Dejak)

Tonya Crenshaw, left, and Kendrick Haraalson fill out applications at a job fair Wednesday, Oct. 26, 2011, in Brookpark, Ohio. The number of people seeking unemployment benefits dipped slightly last week, though not by enough to suggest that hiring is picking up. (AP Photo/Tony Dejak)

Glenn Hoehnen, left, talks with a job seeker at a job fair Wednesday, Oct. 26, 2011, in Brookpark, Ohio. The number of people seeking unemployment benefits dipped slightly last week, though not by enough to suggest that hiring is picking up. (AP Photo/Tony Dejak)

(AP) ? The number of people seeking unemployment benefits dipped slightly last week, though not by enough to suggest that hiring is picking up.

The Labor Department says weekly applications for unemployment benefits declined 2,000 to a seasonally adjusted 402,000. That's the fourth drop in six weeks.

Still, the four-week average, a less volatile measure, rose to 405,500. The average had fallen to a six-month low two weeks ago.

Despite the recent declines, applications are stuck above 400,000, where they have been for all but two weeks since March. Applications need to fall consistently below 375,000 to signal sustainable job growth. They haven't been below that level since February.

Meanwhile, the number of laid-off workers receiving benefits dropped to 3.65 million, the lowest level in three years.

Also Thursday, the government said the economy grew modestly over the summer after nearly stalling in the first six months of the year. It was lifted by stronger consumer spending and business investment.

The economy expanded at an annual rate of 2.5 percent in the July-September quarter. That's nearly double the 1.3 percent growth in the April-June quarter. And it's a vast improvement over the 0.9 percent growth for the entire first half of the year.

Still, while 2.5 percent growth is enough to ease recession fears, it's far below what's needed to lower painfully high unemployment. The rate has been stuck at 9.1 percent for three straight months. Analysts project similar growth for the October-December quarter.

The economy would need to expand by about 4.5 percent for a year to reduce the unemployment rate by a full percentage point. The rate has been near 9 percent for more than 2? years, the longest such stretch since the Great Depression.

Employers have added an average of only 72,000 jobs per month in the past five months. That's far below the 100,000 per month needed to keep up with population growth. And it's down from an average of 180,000 in the first four months of this year.

In September, the economy generated 103,000 net jobs.

There was some positive economic news Wednesday. Companies ordered more heavy machinery, computers and other long-lasting factory goods last month, the Commerce Department said.

Orders for those types of capital goods rose 2.4 percent, the biggest gain in six months. That suggests companies are willing to spend and invest, even with growth slow and consumer confidence at dismal levels.

Sales of new homes also rose in September, the department said in a separate report, though mostly because builders cut prices. Sales are still at about half the level that would be consistent with a healthy economy. Most analysts say the battered housing sector is years away from a turnaround.

The U.S. economy could benefit from the deal European leaders clinched Thursday to have banks take 50 percent losses on Greek debt and raise new capital to protect against defaults on sovereign debt.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-10-27-Unemployment%20Benefits/id-3a91465176fa4733a0d1192fd422d66d

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Israel, Egypt carry out U.S.-brokered prisoner swap (Reuters)

JERUSALEM/TABA, Egypt (Reuters) ? Egypt released an American-Israeli it held as an alleged spy and Israel freed 25 Egyptians in a prisoner swap Thursday that will ease strains between Cairo's new rulers and the United States and Israel.

Ilan Grapel, 27, flew to Israel accompanied by two Israeli envoys sent by Prime Minister Benjamin Netanyahu. The Israeli leader later greeted him at his Jerusalem office and exchanged a firm handshake but few words for the cameras.

Smiling, Grapel embraced his mother who waited on the tarmac at Tel Aviv's Ben Gurion Airport after he climbed out of a private jet with Netanyahu's envoys.

The freed Egyptians crossed overland into Egypt's Sinai desert, some of them kneeling in a thanksgiving prayer.

Egypt arrested Grapel in June on suspicion that he was out to recruit agents and monitor events in the revolt that toppled Hosni Mubarak, an ally of Israel and the United States.

Israel denied that Grapel, who emigrated from New York in 2005 and was wounded as an Israeli paratrooper in the 2006 Lebanon war, was a spy. His links to Israel were apparent on his Facebook page, which contained photos of him in Israeli military uniform.

A law student in the United States, Grapel had been working for Saint Andrew's Refugee Services, a non-governmental agency, when he was detained.

The United States, which provides the army that now runs Egypt with billions of dollars in military aid, had called for Grapel's release. He was freed three weeks after U.S. Defense Secretary Leon Panetta visited Egypt.

The U.S.-brokered exchange deal was reached shortly after a more high-profile, Egyptian-mediated swap between Israel and Gaza's Hamas Islamist rulers freed captive Israeli soldier Gilad Shalit in exchange for more than 1,000 Palestinian prisoners.

Eli Avidar, a former diplomat who headed Israel's mission in Qatar, said securing the release of Egyptian prisoners could help Cairo's new leaders domestically.

"The Egyptian administration needs this for its prestige," he said on Israel Television.

Israel is widely unpopular in Egypt, which signed a peace treaty with its northern neighbor in 1979.

EMBASSY ATTACK

In September, Israel flew its ambassador out of Egypt when the Israeli embassy was attacked by protesters angry at the killings of Egyptian border guards when Israeli troops pursued raiders who killed eight Israelis in August. Israel said the gunmen infiltrated from the Gaza Strip via the Sinai.

Many of the prisoners on the release roster were jailed for drug trafficking, infiltration into Israel and gun-running, but not for espionage or attacks on Israelis, Israel's Prison Service said.

"Raise up your heads, you are Egyptian," cried relatives waving the country's red, white and black flag as the bus carrying the men crossed the border.

"I've been in jail since 2005. Thank God. I feel reborn," Mursi Barakat told Egyptian state television. "The treatment in jail was very tough and it was clear there was discrimination."

U.S. Congressman Gary Ackerman (D-New York) who pressed for Grapel's release, traveled to Israel to accompany him back to the United States, his office said in a statement.

"Congratulations, great work, thank you for everything," Ackerman told Netanyahu when he accompanied Grapel and his mother to the meeting in Jerusalem.

Israel has also called for steps to help free another Israeli, Oudeh Suleiman Tarabin, jailed by Egypt.

Egypt's South Sinai governor Khaled Fouda told reporters after the hand over: "This is the biggest prisoner swap deal since 1948 ... There will be more deals in the future."

Amos Gilad, a senior Israeli Defense Ministry official, rejected arguments by right-wingers in Israel that it had capitulated to Egypt in the 25-1 exchange.

"The bottom line is you have to decide, will he (Grapel) stay there in prison, or not? If you ask, me, he needed to be freed," Gilad said on Israel Radio.

(Additional reporting by Dan Williams and Ori Lewis in Jerusalem and Shaimaa Fayed and Omar Fahmy in Cairo; Writing by Jeffrey Heller and Edmund Blair)

Source: http://us.rd.yahoo.com/dailynews/rss/religion/*http%3A//news.yahoo.com/s/nm/20111027/wl_nm/us_egypt_israel_swap

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